Published 2006 .
Written in EnglishRead online
In vitro studies have shown insulin to have both atherogenic and anti-atherogenic effects whereas the effect of insulin in vivo is still unclear. In the first study I investigated the effect of normoglycemic hyperinsulinemia achieved via oral glucose administration and oral glucose administration alone on neointimal growth 14 days after arterial injury and demonstrated that insulin decreased neointimal growth independent of glucose-lowering or need for oral glucose administration. In the second study I assessed the effect of normoglycemic hyperinsulinemia on matrix metalloproteinases (MMPs) 4 days after arterial injury. MMPs are the main mediators of smooth muscle cell (SMC) migration after arterial injury. I demonstrated that insulin decreased pro-MMP-2 and MMP-2 gelatinolytic activity by decreasing the expression of MMP-2. Insulin also decreased MMP-9 gelatinolytic activity. These results suggest that insulin can reduce intimal growth by decreasing MMP activity. The results from both studies suggest that insulin has anti-atherogenic effects in vivo.
|The Physical Object|
|Number of Pages||126|
Download effect of insulin on neointimal growth and matrix metalloproteinases in the rat model of balloon catheter injury of the carotid artery.